2. Neurological Disease

Neurological Disease

Neurological Disease

Related Products

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-13557R
    Ascomycin (Standard) 104987-12-4
    Ascomycin (Standard) is the analytical standard of Ascomycin. This product is intended for research and analytical applications. Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research[1][2].
    Ascomycin (Standard)
  • HY-135608
    BD-1008 138356-08-8 98.41%
    BD-1008 is a selective sigma 1 (σ1) receptor antagonist with a Ki of 2 nM. BD-1008 exhibits 4-fold selectivity over the sigma-2 receptor (Ki of 8 nM). BD-1008 can be used for the study of neurological diseases.
    BD-1008
  • HY-135628
    PD-85639 149838-21-1 98%
    PD-85639 is a voltage-gated sodium (Na+) channel blocker that has neuroprotective effects.
    PD-85639
  • HY-135649
    Tremorine 51-73-0
    Tremorine is an agent used to induce tremors in animals. Tremorine can be used to establish animal tremor models for the study of Parkinson's disease.
    Tremorine
  • HY-135749
    BN201 1361200-34-1 99.89%
    BN201 promotes neuronal differentiation, the differentiation of precursor cells to mature oligodendrocytes (EC50 of 6.3 μM) in vitro, and the myelination of new axons (EC50 of 16.6 μM). BN201 is able to cross the blood-brain barrier by active transport and activate pathways (IGF-1 pathway) associated with the response to stress and neuron survival. BN201 has potently neuroprotective effects.
    BN201
  • HY-13575S
    Blonanserin-d8 98%
    Blonanserin-d8 is a deuterium labeled Blonanserin. Blonanserin is a dopamine D2/5-HT2 receptor antagonist and an atypical antipsychotic.
    Blonanserin-d8
  • HY-135880
    OMDM-3 616884-64-1 98%
    OMDM-3 is a selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a Ki of 16.6 μM.
    OMDM-3
  • HY-135881
    OMDM-5 616884-66-3 98%
    OMDM-5 is a selective inhibitor of anandamide cellular uptake (ACU), with a Ki of 4.8 μM. OMDM-5 is also a potent vanilloid receptor type 1 (VR1, TRPV1) agonist, with an EC50 of 75 nM, and shows weakly active as cannabinoid receptor type 1 (CB1) ligand (Ki=4.9 μM).
    OMDM-5
  • HY-135895
    Detomidine carboxylic acid 115664-39-6 98%
    Detomidine carboxylic acid is the major urinary metabolite of Detomidine. Detomidine is a synthetic α2-adrenergic agonist. Detomidine also has cardiac and respiratory effects and an antidiuretic action.
    Detomidine carboxylic acid
  • HY-136092
    Androsta-1,4,6-triene-3,17-dione 633-35-2 98%
    Androsta-1,4,6-triene-3,17-dione is a lipophilic and specific aromatase inhibitor with a Ki of 0.18 μM. Androsta-1,4,6-triene-3,17-dione inhibits estrogen biosynthesis and shows antifertility effects. Androsta-1,4,6-triene-3,17-dione induces impairment of spatial memory.
    Androsta-1,4,6-triene-3,17-dione
  • HY-136094
    SRT3657 1383551-17-4 98%
    SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect.
    SRT3657
  • HY-136189
    UK-59811 hydrochloride 2250025-89-7 98%
    UK-59811 hydrochloride, a Br-dihydropyridine derivative, is a potent bacterial homotetrameric model voltage-gated Ca2+ (CaV) channel CaVAb inhibitor with an IC50 of 194 nM.
    UK-59811 hydrochloride
  • HY-136232
    PSEM 308 hydrochloride 98%
    PSEM 308 hydrochloride is a pharmacologically selective actuator module (PSAM) agonist. PSEM 308 Activates PSAML141F-GlyR chimeric ion channels.
    PSEM 308 hydrochloride
  • HY-136238
    PM226 1949726-13-9 98%
    PM226 is a selective cannabinoid CB2R agonist (Ki (CB2R)=13 nM; EC50 (CB2R)=39 nM; Ki (CB1R) >40 μM;) with neuroprotective properties in vitro and vivo.
    PM226
  • HY-136258
    nAChR agonist CMPI hydrochloride 2250025-94-4 98%
    nAChR agonist CMPI hydrochloride is a potent and selective positive allosteric modulator (PAM) of nAChR containing a α4:α4 subunit interface. nAChR agonist CMPI hydrochloride enhances the response of (α4)3(β2)2 nAChR to ACh (10 µM) with an EC50 of 0.26 µM. nAChR agonist CMPI hydrochloride has potential for the research of nicotine dependence and many neuropsychiatric conditions associated with decreased brain cholinergic activity.
    nAChR agonist CMPI hydrochloride
  • HY-136283
    DMNPE-4 AM-caged-calcium 2253744-58-8 98%
    DMNPE-4 AM-caged-calcium, photolabile analogues of EGTA, is an extremely effective Ca2+ selective cage, with a Kd for Ca2+ of 48 nM and 19 nM at pH 7.2 and pH 7.4, respectively. DMNPE-4 AM-caged-calcium has a lower affinity for Ca2+ (Kd=~2 nM) after photolysis.
    DMNPE-4 AM-caged-calcium
  • HY-13630R
    Etoposide phosphate (Standard) 117091-64-2
    Etoposide phosphate (Standard) is the analytical standard of Etoposide phosphate. This product is intended for research and analytical applications. Etoposide phosphate (BMY-40481) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate is the phosphate ester proagent of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate induces cell cycle arrest, apoptosis, and autophagy.
    Etoposide phosphate (Standard)
  • HY-136471
    Anticonvulsant agent 6 87213-50-1 98%
    Anticonvulsant agent 6 (Compound V) is a benzodiazepine compound with anticonvulsant and central depressant effects.
    Anticonvulsant agent 6
  • HY-136480
    Chrysamine G 6472-91-9 98%
    Chrysamine G, a carboxylic acid analogue of Congo Red, can be used as a probe of amyloid deposition in Alzheimer's disease. Chrysamine G also can inhibit Aβ-induced toxicity in PC12 cells.
    Chrysamine G
  • HY-136487
    Buspirone N-oxide 220747-81-9 98%
    Buspirone N-oxide (Bu N-oxide) is a metabolite of Buspirone (HY-B1115A). Buspirone is an orally active 5-HT1A receptor agonist, and a dopamine D2 autoreceptorsant antagonist. Buspirone is an anxiolytic agent, and can be used for the generalized anxiety disorder research.
    Buspirone N-oxide
Cat. No. Product Name / Synonyms Application Reactivity